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Current advances in urban leptospirosis diagnosis

Sayyed Mousavi, Mir Nasera,b; Sadeghi, Javidc; Aghazadeh, Mohammadd; Asgharzadeh, Mohammade; Samadi Kafil, Hosseina

Reviews in Medical Microbiology: July 2017 - Volume 28 - Issue 3 - p 119–123
doi: 10.1097/MRM.0000000000000110

Leptospirosis is generally significant zoonotic disease and an important public health problem in developing countries. Because of primary antibiotic treatment importance in this disease, early diagnosis is essential for appropriate managing. Laboratory tests for the early diagnosis of disease are necessary. PCR is not sole useful for diagnosis, as it is unavailable in most developing countries. Microscopic agglutination test and the ELISA are not suitable leptospirosis tests for early diagnosis, but they can be taken as gold standard methods for leptospirosis diagnosis, especially as complementary tests in a corelation with molecular methods. Leptospirosis detection rate is increased by combining antibody and DNA detection, providing a new tool for timely diagnosis and confirmation of infection.

aDrug Applied Research Center

bStudent Research Committee

cImmunology Research Center

dInfectious and Tropical Disease Research Center

eBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Correspondence to Hossein Samadi Kafil, PhD, Assistant Professor, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Tel: +98 9127184735; fax: +98 4113364661; e-mail:

Received 9 December, 2016

Revised 12 April, 2017

Accepted 13 April, 2017

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