BACTERIOLOGYCarvacrol and thymol: strong antimicrobial agents against resistant isolatesMemar, Mohammad Y.a,b; Raei, Parisac; Alizadeh, Naserb,d; Akbari Aghdam, Masouda; Kafil, Hossein Samadid Author Information aInfectious and Tropical Disease Research Center bStudent Research Committee cDrug Applied Research Center dBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Correspondence to Hossein Samadi Kafil, PhD, Assistant Professor, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Tel: +98 9127184735; fax: +98 4133364661; e-mail: [email protected] Received 21 October, 2016 Revised 2 February, 2017 Accepted 7 February, 2017 Reviews in Medical Microbiology: April 2017 - Volume 28 - Issue 2 - p 63-68 doi: 10.1097/MRM.0000000000000100 Buy Metrics Abstract Antibiotics have been effective in treatment of infectious diseases, but resistance to these drugs has led to the severe consequences. In recent years, medicinal herbs have been used for the prevention and protection against infectious diseases. Thymol and carvacrol are active ingredients of family Lamiaceae; these components have antibacterial and antifungal effects. In this review, we survey antimicrobial properties of carvacrol and thymol. Available data from different studies (microbiological, retrieve from PubMed, and Scopus databases) about antimicrobial affects carvacrol and thymol was evaluated. Carvacrol and thymol can inhibit the growth of both gram-positive and gram-negative bacteria. These compounds have antifungal and antibiofilm effects. Thymol and carvacrol can also be applied as an alternative antimicrobial agent against antibiotic-resistant pathogenic bacteria. Thus, thymol and carvacrol are recommended for potential medical use; however, more research is required on toxicity and side-effects of the compounds. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.