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AIDS-related malignancies

Qadir, Muhammad I.a; Abbas, Khizarb; Qadeer, Kahkashanb; Abid, Ammanb

Reviews in Medical Microbiology: January 2016 - Volume 27 - Issue 1 - p 1–8
doi: 10.1097/MRM.0000000000000055

There is a high risk of developing malignancies in persons infected with HIV. The most common AIDS-related cancer is Kaposi's sarcoma, which is caused by Kaposi's sarcoma-linked herpesvirus. Others are invasive cervical cancer and non-Hodgkin's lymphoma caused by human papillomavirus and Epstein–Barr virus, respectively. Among the chemotherapeutic agents, pegylated liposomal doxorubicin is an effective therapy for patients with HIV-linked Kaposi's sarcoma. There is also a chance of developing non-AIDS-related cancers, for example, Hodgkin's disease and multiple myeloma. Use of highly active antiretroviral therapy is very important for controlling the malignancies, as well as the occurrence of long-term infections and prognosis.

aInstitute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan

bCollege of Pharmacy, GC University, Faisalabad, Pakistan.

Correspondence to Muhammad I. Qadir, Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.Tel: +92 301 6515613; e-mail:

Received 20 March, 2015

Revised 10 April, 2015

Accepted 10 April, 2015

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