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Fatal multiple organ failure in an adolescent due to community-acquired methicillin-susceptible Staphylococcus aureus ST121/agrIV lineage: case report and review

Rao, Qinga; Shang, Weilonga; Zhou, Kunb; Zhou, Renjieb; Rao, Xiancaia

Reviews in Medical Microbiology: November 2015 - Volume 26 - Issue 4 - p 163–167
doi: 10.1097/MRM.0000000000000050

Adolescent deaths due to Staphylococcus aureus infection are rare. We describe the case of a 17-year-old boy who died from septic multiple organ failure caused by community-acquired methicillin-susceptible S. aureus. The patient's first clinical symptom was a skin and soft tissue infection, with multiple organ failure developing 5 days afterwards. The causative organism S. aureus was further determined to carry Panton-Valentine leukocidin genes, and molecularly characterized as staphylococcal protein A (spa) type t159, multilocus sequence type (ST)121, and accessory gene regular (agr) type IV. ST121/agrIV S. aureus is one of the minor lineages prevailing in China, and this is the first fatal case reported due to ST121/agrIV lineage of community-acquired methicillin-susceptible S. aureus in the country.

aDepartment of Microbiology, College of Basic Medical Sciences, Third Military Medical University

bDepartment of Emergency, Xinqiao Hospital, Chongqing, China.

Correspondence to Xiancai Rao, PhD, Department of Microbiology, College of Basic Medical Sciences, Third Military Medical University, 30# Gaotanyan St, Shapingba District, Chongqing 400038, China. Tel/fax: +86 23 68752240; e-mail:

Received 14 January, 2015

Revised 31 March, 2015

Accepted 31 March, 2015

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