BACTERIOLOGYThe role of filamentous CTXphi bacteriophage in Vibrio cholerae genetics and diversityBakhshi, BitaAuthor Information Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Correspondence to Bita Bakhshi, PhD, Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Jalal-Ale-Ahmad Ave, Tehran 14115-331, Iran. Tel: +982182884558; fax: +982182884555; e-mail: firstname.lastname@example.org Received 24 May, 2014 Revised 29 May, 2014 Accepted 29 June, 2014 Reviews in Medical Microbiology: April 2015 - Volume 26 - Issue 2 - p 43-46 doi: 10.1097/MRM.0000000000000017 Buy Metrics Abstract Cholera toxin is the most important virulence factor of epidemic Vibrio cholerae strains. It is encoded by ctxAB operon that is a part of the genome of a filamentous bacteriophage (CTXphi). This bacteriophage plays an important role in the evolution and pathogenesis of V. cholerae and genetic variations that occur within the genome of this bacteriophage affect V. cholerae toxicity and potential to cause epidemics and can be used as a powerful tool in epidemiological investigations. Copyright © Wolters Kluwer Health, Inc. All rights reserved.