PATHOGENICITYLeptospiral major outer membrane protein LipL32Ghazaei, CiamakAuthor Information Department of Microbiology, University of MohagheghArdabili, Ardabil, Iran. Correspondence to Ciamak Ghazaei, Department of Microbiology, University of MohagheghArdabili, P.O. Box 179, Ardabil, Iran. Tel: +98 451 5512081 9; fax: +98 451 5510803; e-mail: email@example.com Received 9 July, 2014 Revised 4 September, 2014 Accepted 4 September, 2014 Reviews in Medical Microbiology: April 2015 - Volume 26 - Issue 2 - p 65-69 doi: 10.1097/MRM.0000000000000022 Buy Metrics Abstract Leptospirosis is now considered a re-emerging infectious disease and may become a severe threat to both developing and developed countries. Technological developments in the last 10 years identified several potential candidate proteins to play significant roles in pathogenesis. Many of these candidate proteins proved to be vital in disease diagnosis and treatment. The 32-kDa lipoprotein (LipL32) is the major surface protein present on pathogenic strains of Leptospira. The involvement of LipL32 in pathogenesis of Leptospirosis has been studied extensively and different lines of evidence indicate that LipL32 is a lipid-modified membrane protein that is similar to several other prokaryotic lipoproteins. This review focuses on LipL32 and its role as a therapeutic and diagnostic target. Copyright © Wolters Kluwer Health, Inc. All rights reserved.