ANTIBIOTIC RESISTANCERoles of integrons in the antimicrobial resistance of Gram-positive microorganismsDeng, Yanga; Liang, Yanruia; Cui, Hemiaoa; Zhao, Xihongb; Zhong, Nanjingc; Li, Yanyand; Chen, Dingqiange; Bian, Huaweif; Li, Yanmeia,g,h; Yu, GuangchaoiAuthor Information aCollege of Light Industry and Food Sciences, South China University of Technology, Guangzhou bKey Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan cSchool of Food Science, Guangdong Pharmaceutical University, Zhongshan dState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi eDepartment of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical College fThe Third Affiliated Hospital of Sun Yat-sen University gGuangzhou Medical University Guangzhou, China hDepartment of Microbial Pathogenesis, University of Maryland, Baltimore, MD, USA iFirst Affiliated Hospital of Jinan University, Guangzhou, China. Correspondence to Yanmei Li, PhD, 195 Dongfeng Xi Road, Guangzhou 510182, China. Tel: +86 20 81340448; fax: +86 20 81340448; e-mail: [email protected] Received 28 April, 2014 Revised 1 June, 2014 Accepted 1 June, 2014 Reviews in Medical Microbiology: January 2015 - Volume 26 - Issue 1 - p 26-31 doi: 10.1097/MRM.0000000000000014 Buy Metrics Abstract Gram-positive microorganisms comprise one of the leading pathogenic microorganisms in public health, including several ‘Superbugs’ such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, which have posed a dilemma for the treatment of infectious diseases caused by Gram-positive bacteria and will consequently result in an increasing number of clinical failures. Integrons have been established as a significant resistance determinant and shown to contribute to the multiresistance of microorganisms; however, its role in antimicrobial resistance in Gram-positive microorganisms still remains unclear and somehow neglected. In the last decade, integron surveillance has been conducted for various clinical microorganisms in Guangzhou, China, and based on this study this review aims at summarizing the occurrence and prevalance of integrons and their role in the antimicrobial resistance of Gram-positive microorganisms. Copyright © Wolters Kluwer Health, Inc. All rights reserved.