PATHOGENICITYLeptospiral outer membrane proteins and fibronectin in host–pathogen interactionGhazaei, CiamakAuthor Information Department of Microbiology, University of Mohaghegh Ardabili, Ardabil, Iran. Correspondence to Ciamak Ghazaei, Department of Microbiology, University of Mohaghegh Ardabili, PO Box 179, Ardabil, Iran. Tel: +451 5512081-9; fax: +451 5510803; e-mail: [email protected] Received 18 May, 2014 Revised 28 July, 2014 Accepted 28 July, 2014 Reviews in Medical Microbiology: January 2015 - Volume 26 - Issue 1 - p 32-35 doi: 10.1097/MRM.0000000000000019 Buy Metrics Abstract Leptospirosis is a widespread zoonotic disease caused by the spirochaete Leptospira, which is an invasive pathogen. There are more than 200 serovars of the pathogen, causing significant morbidity and mortality especially in tropical countries. Many Third World countries report outbreaks of leptospirosis during the rainy season. The last few decades witnessed an increase in awareness of the biology and pathogenesis of leptospirosis, its life-cycle, infection, disease development, clinical manifestations of leptospirosis, immune response, and mode of dissemination. Although not fully understood, a considerable amount of information is available on the mechanism involved in the invasion of the pathogen in humans and other animals. Two major groups of proteins, the proteases and the membrane proteins, are thought to be involved in the invasion of pathogen to target tissues. This review discusses recent developments involving extracellular matrix components, especially fibronectin and outer membrane proteins, in the mechanism of infection. Copyright © Wolters Kluwer Health, Inc. All rights reserved.