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Archaeosomes as means of nano-drug delivery

Moghimipour, Eskandara,b; Kargar, Mohammadc; Handali, Somayehb

Reviews in Medical Microbiology: April 2014 - Volume 25 - Issue 2 - p 40–45
doi: 10.1097/MRM.0000000000000000
Review articles

Archaeosomes are a novel generation of liposomes that are made from polar ether lipids extracted from the Archaea. They have higher stabilities in acidic or alkaline pH, bile salts, high temperatures and against phospholipase, oxidation, chemical and enzymatic hydrolysis in comparison with conventional liposomes. Ether links are more stable than ester links. The ability of Archaea to adapt their membrane lipid compositions to harsh environments has resulted in archaeal lipids to be considered for the development of nano-drug delivery capable of overcoming the biophysical, biological and biomedical barriers that the body displays towards gene, drug and vaccine therapies. Archaeosomes are prepared from various type of Archaea which show high adjuvant activity and can promote humoral and cell-mediated immune responses. In-vitro and in-vivo studies indicate that archaeosomes are safe and can be used in biotechnology applications such as drug, gene and vaccine delivery.

aCellular and Molecular Research Center

bNanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz

cDepartment of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran.

Correspondence to Somayeh Handali, Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Tel: +98 9161147998; fax: +98 6113738381; e-mail:

Received 21 July, 2013

Revised 8 September, 2013

Accepted 8 September, 2013

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins