VIROLOGYThe small subunit of ribonucleotide reductase gene and protein of herpes virusesWei, Mina,*; Cheng, An-chuna,b,c,*; Wang, Ming-shua,b,c,*Author Information aInstitute of Preventive Veterinary Medicine bAvian Disease Research Center, College of Veterinary Medicine cKey Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, Sichuan, China. *Min Wei, An-chun Cheng and Ming-shu Wang contributed equally to the writing of this article. Correspondence to Anchun Cheng, Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, Sichuan 611130, China. E-mail: [email protected] Reviews in Medical Microbiology: October 2012 - Volume 23 - Issue 4 - p 82-85 doi: 10.1097/MRM.0b013e3283573668 Buy Metrics Abstract Herpes virus ribonucleotide reductase, which consists of two nonidentical subunits, designated R1 and R2, is an essential enzyme responsible for reduction of four ribonucleoside diphosphates to corresponding deoxyribonucleoside diphosphates, and it is the rate-limiting step in DNA synthesis. The R2 subunit contains a tyrosyl-free radical and a binuclear μ-oxo bridged iron center, which are required for ribonucleotide reductase activity. The characters of herpes viruses R2 gene and protein are described in the present article. © 2012 Lippincott Williams & Wilkins, Inc.