ArticleCharacteristics and function of the UL34 gene and its encoding protein in herpesvirusZhong, Xiao-Ronga,b,*; Cheng, An-Chuna,c; Wang, Ming-Shua,c; Gong, Yong-Qiangd,*Author Information aAvian Disease Research Center, College of Veterinary Medicine of Sichuan, Agricultural University, Yaan, China bEnvironmental Monitoring of Chongqing City, Hechuan, China cKey Laboratory of Animal Disease and Human Health of Sichuan Province, Yaan, China dLaboratory of Animal Health Inspection of Chongqing city, Hechuan, China. *Xiao-Rong Zhong and Yong-Qiang Gong contributed equally to the writing of this article. Received 19 November, 2010 Accepted 27 December, 2010 Correspondence to An-Chun Cheng, Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Yaan 625014, China. Tel: +86 835 2885774; e-mail: [email protected] Reviews in Medical Microbiology: April 2011 - Volume 22 - Issue 2 - p 22-27 doi: 10.1097/MRM.0b013e32834420ee Buy Metrics Abstract The herpesvirus UL34 gene is highly conserved in the Herpesviridae family. The nucleotide sequence has the characteristic of comparatively high content of G + C and the gene product is a tail-anchored type II membrane protein involved in the primary envelopment of capsid in the endoplasmic reticulum, profiting the virion maturation and nucleocapsid budding, regulating the proper location of the UL31 protein and lamin in infected cells. In this work, we summarize the research progress on characteristic and function of the UL34 gene and its encoding protein to provide some new insights into the molecular biology of herpesvirus and its mechanism of replication. © 2011 Lippincott Williams & Wilkins, Inc.