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Update of hybridization-based methods for the rapid diagnosis of sepsis

Liao, Qiu-Xia; Qian, Yan-Li; Wang, Pei

Reviews in Medical Microbiology: October 2010 - Volume 21 - Issue 4 - p 80–83
doi: 10.1097/MRM.0b013e32833e69f7

Conventionally in-situ hybridization (ISH) is used for the study of chromosome structure/function and cytological analysis. With the growing availability of microbial genomic maps and requirement of high sensitivity, specificity and short time for microbiological diagnostic assays, ISH has been introduced into clinical microbiology for rapid diagnosis of sepsis; diverse of ISH-based methods have been promoted by means of novel probe, label and automated hybridization system. ISH has become a leading diagnostic technique for sepsis diagnosis. This review summarizes common hybridization assays in relation to sepsis diagnosis.

The First People's Hospital of Jingmen, Hubei, China.

Received 22 June, 2010

Accepted 19 July, 2010

Correspondence to Pei Wang, Division of Clinical Microbiology, Department of Laboratory Medicine, The First People's Hospital of Jingmen, Hubei 448000, China. Tel: +86 724 2305781; fax: +86 724 2305687; e-mail:

© 2010 Lippincott Williams & Wilkins, Inc.