BACTERIAL INFECTIONSHeat shock protein A of Helicobacter pylori: a promising vaccine candidateGong, Fanghong; He, Song; Zhang, Dechun; Guo, YananAuthor Information Molecular Medicine & Tumor Research Center, Chongqing Medical University, Chongqing, China. Received 5 September, 2009 Revised 16 October, 2009 Accepted 18 October, 2009 Correspondence to Fanghong Gong, Chongqing Medical University, 1 Yi xue yuan Road, Chongqing 400016, China. Tel: +86 23 68486133; e-mail: email@example.com Reviews in Medical Microbiology: January 2010 - Volume 21 - Issue 1 - p 1-6 doi: 10.1097/MRM.0b013e3283361df9 Buy Metrics Abstract Helicobacter pylori (H. pylori) is a spiral Gram-negative microaerophilic bacterium colonizing the human gastric mucosa. Infection with H. pylori has been recognized as the leading cause of specific gastroduodenal diseases. Because eradication requires treatment with multidrug regimens, controlling this global problem by vaccination is attractive. Extensive studies have demonstrated the feasibility of both prophylactic and therapeutic immunizations. However, most efforts have so far achieved limited success. This is partly due to the fact that neither an optimal composition of protective antigens nor the major protective immune mechanisms in humans have been identified. In this review, we describe the properties of heat shock protein A (HspA), such as its structural conservation and good immunogenicity, as one of the candidate antigens with most potential and its inclusion in an H. pylori vaccine. © 2010 Lippincott Williams & Wilkins, Inc.