CLINICAL VIROLOGY: PDF OnlyHepatocellular carcinoma associated with chronic hepatitis B and C: pathogenesis, treatment and preventionRoy, Kirsty M.; McMenamin, Jim*Author Information University of Glasgow Dental School and the Scottish Centre for Infection and Environmental Health, and *Department of Public Health, University of Glasgow and the Scottish Centre for Infection and Environmental Health, Scotland Address for correspondence: Dr K. M. Roy, University of Glasgow Dental School, 378 Sauchiehall Street, Glasgow G2 3JC, Scotland. Fax: 44 (0) 141 353 1593. e-mail: [email protected] Reviews in Medical Microbiology: July 2000 - Volume 11 - Issue 3 - p 171-178 Buy Abstract Primary liver cancer, of which hepatocellular carcinoma (HCC) is the dominant histological subtype, is the third most common cancer in males and the sixth most common cancer in females world-wide. The differing geographical prevalence of HCC in high and low incidence areas of the world reflects the varying prevalence of HBV and HCV infection. Chronic infection with the hepatitis virus (types B and C) is an important cause of HCC accounting for approximately 77% of cases. HCC is difficult to treat and has a poor prognosis with most tumours diagnosed at an advanced stage. The pathogenesis of both HBV- and HCV-related HCC is poorly understood, restricting the identification of targets for treatment. Primary or secondary prevention of HBV through vaccination should dramatically reduce the number of cases of HBV-associated liver disease and HCC. Unfortunately no vaccine exists for the prevention of HCV. Treatment of individuals already chronically infected with hepatitis B or C is important from the perspective of public health to limit spread, and to the individual to prevent progression to cirrhosis or carcinogenesis. However, because of the high cost of the currently available agents, the restrictive eligibility criteria usually used for their use and the extensive adverse effects associated with them, this will remain a challenge to the medical and allied professions. © 2000 Lippincott Williams & Wilkins © 2000 Lippincott Williams & Wilkins, Inc.