ORIGINAL ARTICLE: PDF OnlyChallenges in vaccinologyPoolman, Jan T.Author Information Laboratory of Vaccine Development and Immune Mechanisms, National Institute for Public Health and Environmental Protection, PO Box 1, 3720 BA Bilthoven, The Netherlands Reviews in Medical Microbiology: April 1996 - Volume 7 - Issue 2 - p 73-82 Buy Abstract The science of vaccinology, i.e. the induction of immune responses for the prevention and treatment of infectious and chronic diseases, will lead to better understanding of the immune mechanisms involved and technological ways to trigger these. This article describes the current situation with respect to the large-scale application of microbial vaccines and describes the various components of the adaptive immune system, the effector and memory B, CD4+ and CD8+ T cells. New vaccine technologies such as antigen delivery, adjuvants, synthetic constructs, nucleic acid vaccines, live vectors and mucosal immunization are described. Possibilities for the improvement of existing vaccines and the development of new vaccines are noted. © Williams & Wilkins 1996. All Rights Reserved.