Case ReportSURGICAL MANAGEMENT OF FULL-THICKNESS MACULAR HOLE SUPERIMPOSED ON EXUDATIVE AGE-RELATED MACULAR DEGENERATIONShif, Olga A. MD; Katz, Matthew S. J. MDAuthor Information National Retina Institute, Towson, Maryland Reprint requests: Olga A. Shif, MD, National Retina Institute, 901 Dulaney Valley Road, Suite 200, Towson, MD 21204; e-mail: [email protected] None of the authors has any financial/conflicting interests to disclose. Retinal Cases & Brief Reports: May 2021 - Volume 15 - Issue 3 - p 211-213 doi: 10.1097/ICB.0000000000000786 Buy Metrics AbstractIn Brief Background/Purpose: We describe a case of full-thickness macular hole formation in a patient with exudative age-related macular degeneration after an intravitreal ranibizumab injection and its surgical management. Methods: This case is a retrospective, interventional case report. Results: A 77-year-old woman with bilateral exudative age-related macular degeneration and pre-existing retinal pigment epithelium tear developed a full-thickness macular hole after intravitreal ranibizumab. The macular hole was repaired successfully with pars plana vitrectomy, internal limiting membrane peel, and 16% C3F8 gas fill. Conclusion: To the best of our knowledge, this is the first reported case of full-thickness macular hole after a retinal pigment epithelium tear repaired successfully with vitrectomy, resulting in improved visual acuity. Retinal pigment epithelium tears seldom occur after intravitreal anti–vascular endothelial growth factor medications in exudative age-related macular degeneration. Few case reports have described patients with full-thickness macular hole formation after retinal pigment epithelium tears following anti–vascular endothelial growth factor treatments. We explore a surgical approach of full-thickness macular hole repair in a patient with wet age-related macular degeneration with a retinal pigment epithelium tear with successful anatomical and visual results.