Case ReportPERSISTENT PLACOID MACULOPATHY IN A PATIENT WITH HIGH MYOPIAKolomeyer, Anton M. MD, PhD; Brucker, Alexander J. MDAuthor Information Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania. Reprint requests: Alexander J. Brucker, MD, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 51 N. 39th Street, Philadelphia, PA 19104; e-mail: [email protected] None of the authors has any financial/conflicting interests to disclose. Retinal Cases & Brief Reports: May 2021 - Volume 15 - Issue 3 - p 197-201 doi: 10.1097/ICB.0000000000000818 Buy Metrics AbstractIn Brief Purpose: To describe a case of persistent placoid maculopathy in a patient with high myopia. Methods: Interventional case report. Results: A 59-year-old white man with high myopia presented with blurriness in the left eye. Vision was 20/20 bilaterally. Optical coherence tomography showed subretinal thickening and fluid without definitive leakage on fluorescein angiography after which anti–vascular endothelial growth factor (anti-VEGF) therapy was initiated. The patient was diagnosed with persistent placoid maculopathy based on multimodal imaging and clinical response. His disease course was characterized by multiple bilateral recurrences despite active treatment. At final visit (23 months after presentation), the vision was 20/20 in the right eye and 20/25 in the left eye, and the disease remained quiescent on immunomodulating therapy. Conclusion: Prompt initiation of anti-VEGF injections and immunosuppression resulted in disease control and preservation of vision in both eyes for almost 2 years. Persistent placoid maculopathy is a bilateral idiopathic chorioretinopathy most commonly diagnosed in white men in the 6th to 7th decade of life. In the following, we describe a case of persistent placoid maculopathy in a patient with high myopia who required multiple immunosuppressive medications to maintain disease quiescence and preserve vision.