Case ReportDOCUMENTATION OF A NEW CHOROIDAL NEVUSParikh, Ravi MD, MPH*,†; Gal-Or, Orly MD*,†,‡; Sakurada, Yoichi MD, PhD*,†,§; Leong, Belinda MD*,†; Freund, K. Bailey MD*,†,¶ Author Information *LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York; †Vitreous Retina Macula Consultants of New York, New York, New York; ‡Department of Ophthalmology, Rabin Medical Center, Tel-Aviv, Israel; §Departments of Ophthalmology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan; and ¶Department of Ophthalmology, New York University School of Medicine, New York, New York. Reprint requests: K. Bailey Freund, MD, Vitreous Retina Macula Consultants of New York, 460 Park Avenue, New York, NY 10022; e-mail: [email protected] K. B. Freund is a consultant for Optovue, Heidelberg Engineering, Zeiss, Allergan, and Novartis. He receives research support from Genentech/Roche. The remaining authors have no any financial/conflicting interests to disclose. Retinal Cases & Brief Reports: May 2021 - Volume 15 - Issue 3 - p 202-206 doi: 10.1097/ICB.0000000000000822 Buy Metrics AbstractIn Brief Purpose: To describe the occurrence of an acquired choroidal nevus in a 73-year-old white man. Methods: Case report. Results: A 73-year-old white man was referred for an evaluation and treatment of macular changes in his left eye consistent with pachychoroid neovasculopathy. Baseline funduscopic examination and color fundus photographs showed two small peripheral choroidal nevi in the right eye and a single small choroidal nevus in the far temporal macula of the left eye. Treatment with intravitreal aflibercept was initiated in the left eye on a treat-and-extend dosing regimen. Approximately 1 year later, a new pigmented choroidal lesion was detected in the left macula in an area where previous high-resolution color fundus photographs had shown no abnormal pigmentation. Swept-source optical coherence tomography of the new pigmented lesion showed flat hyperreflectivity within the inner choroid consistent with a small choroidal nevus. The patient was referred to his internist who found no evidence of an occult malignancy. Over the course of more than 4 additional years of continuous follow-up, the new choroidal nevus remained stable, no new fundus abnormalities were detected in either eye, and the patient remained medically stable. Conclusion: To the best of our knowledge, this is the first documented case of a new choroidal nevus. Multimodal imaging performed before lesion detection and over the ensuing 4 years showed its stability, thus allowing for the conclusion that it was a benign choroidal nevus rather than a neoplastic or paraneoplastic process. Through multimodal imaging, we show the occurrence of a new choroidal nevus occurring in an adult patient. Multimodal imaging performed before lesion detection and documenting more than 4 years of lesion stability were instrumental in establishing the diagnosis and ruling out a neoplastic or paraneoplastic etiology.