Case ReportMACULAR HOLE FORMATION FOLLOWED BY SPONTANEOUS CLOSURE AFTER PNEUMATIC RETINOPEXY IN A PATIENT WITH DIABETIC MACULAR EDEMACohen, Michael N. MD; Baumal, Caroline R. MDAuthor Information Retina Service at the New England Eye Center, Tufts University Medical Center, Boston, Massachusetts. Reprint requests: Caroline R. Baumal, MD, New England Eye Center, Tufts University Medical Center, 800 Washington Street, Suite 450, Boston, MA 02111; e-mail: [email protected]g None of the authors has any financial/conflicting interests to disclose. Retinal Cases & Brief Reports: Winter 2021 - Volume 15 - Issue 1 - p 24-26 doi: 10.1097/ICB.0000000000000744 Buy Metrics AbstractIn Brief Purpose: To report early formation and spontaneous closure of a full-thickness macular hole that developed after successful pneumatic retinopexy in a patient who had been undergoing treatment for diabetic macular edema. Methods: Case report of a 68-year-old man with bilateral nonproliferative diabetic retinopathy who was currently undergoing anti–vascular endothelial growth factor treatment for bilateral diabetic macular edema. Results: On presentation, visual acuity was 20/200 in the left eye, and examination revealed a bullous, macula-off retinal detachment with a single horseshoe tear at 12 o'clock in the left eye. Pneumatic retinopexy was performed followed by laser augmentation 3 days later. Three weeks postoperatively, he returned with visual acuity of 20/50 and a full-thickness macular hole in the left eye. Although he elected for initial observation, he returned 2 weeks later with visual acuity of 20/50 in both eyes and a retinal detachment with a single break at 10 o'clock in the right eye. The macular hole in the left eye had spontaneously resolved. Pneumatic retinopexy was performed to the right eye. Over 1 year after bilateral pneumatic retinopexy, his retina remains without recurrence of a macular hole in the left eye. Conclusion: In the early postoperative period after pneumatic retinopexy to repair a retinal detachment, a macular hole can form and spontaneously close. This case report describes early formation and spontaneous closure of a full-thickness macular hole that developed after successful pneumatic retinopexy in a patient undergoing treatment for diabetic macular edema.