To report cases that showed partition-like, dark areas in the cone mosaic on adaptive optics scanning laser ophthalmoscopy (AO-SLO) images in eyes with inner nuclear layer (INL) microcystic changes.
Eyes with INL microcystic changes were imaged by prototype AO-SLO.
An eye with Leber hereditary optic neuropathy, an eye with traumatic optic neuropathy, and an eye with retinitis pigmentosa that showed microcystic lesions in the INL were imaged by AO-SLO. The images revealed characteristic, dark, partition-like lesions in the cone mosaic of all the eyes in areas where microcystic changes in the INL were shown by spectral domain optical coherence tomography. The AO-SLO findings in eyes with optic neuropathy were quite similar in shape and size to those seen in eyes with retinitis pigmentosa.
We report cases that manifest dark, partition-like areas in the cone mosaic on AO-SLO images. Microcystic lesions in the INL may affect the images of the cone mosaic.
The authors report cases with dark, partition-like areas in the cone mosaic observed on adaptive optics scanning laser ophthalmoscopy images in eyes with Leber hereditary optic neuropathy, traumatic optic neuropathy, and retinitis pigmentosa. Microcystic lesions in the inner nuclear layer seem to affect the images of the cone mosaic.
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Reprint requests: Sotaro Ooto, MD, Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shougoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; e-mail: email@example.com
Supported in part by the Japan Society for the Promotion of Science, Tokyo, Japan (Grant-in-Aid for Scientific Research, No. 26893131), as well as by the Innovative Techno-Hub for Integrated Medical Bio-Imaging of the Project for Developing Innovation Systems—a project of the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
N. Yoshimura is a paid advisory board member for NIDEK; he has received lecture fees and research funding from NIDEK, Topcon, and Canon. Canon Inc. provided a prototype AO-SLO system to the authors' institution. The remaining authors have no conflicting interests to disclose.