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Lin, Albert B., BS*; Sheyman, Alan T., MD*,†; Jampol, Lee M., MD*

Retinal Cases and Brief Reports: January 2019 - Volume 13 - Issue 1 - p 1–4
doi: 10.1097/ICB.0000000000000540
Case Report

Background/Purpose: To report an unusual appearance of severe bilateral serous detachments in a patient with Waldenstrom macroglobulinemia.

Methods: A case report of a Fifty-six–year-old female patient with Waldenstrom macroglobulinemia.

Results: A patient with Waldenstrom macroglobulinemia presented with serous retinal detachments at the time of diagnosis with Waldenstrom. The patient's IgM levels remained abnormally elevated in the initial stages of her disease course, leading to dramatic ocular findings and images on optical coherence tomography. Chemotherapy was initiated and IgM levels slowly declined, with some improvement in macular fluid as IgM normalized.

Conclusion: Waldenstrom macroglobulinemia may lead to dramatic retinal pathology if IgM levels remain elevated. Prompt chemotherapy and reduction of immunoglobulin levels should be undertaken to preserve retinal architecture.

The authors present the case of a patient with Waldenstrom macroglobulinemia who developed dramatic retinal architecture abnormalities after a prolonged period of sustained elevated IgM levels.

*Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and

Department of Ophthalmology and Visual Sciences, School of Medicine, University of Maryland, Baltimore, Maryland.

Reprint requests: Lee M. Jampol, MD, Department of Ophthalmology, Northwestern University, 645 North Michigan Ave., Ste. 440, Chicago, IL 60611; e-mail:

Supported by a grant from the Research to Prevent Blindness organization, New York City.

None of the authors has any conflicting interests to disclose.

© 2019 by Ophthalmic Communications Society, Inc.