Case ReportPARANEOPLASTIC VITELLIFORM MACULOPATHY IN THE SETTING OF CHOROIDAL MELANOMA: EVOLUTION OVER ONE YEARNagiel, Aaron MD, PhD*; Rootman, Daniel B. MD†,‡; McCannel, Tara A. MD, PhD*,‡Author Information *Retina Division, Stein Eye Institute, Los Angeles, California; †Orbital and Ophthalmic Plastic Surgery Division, Stein Eye Institute, Los Angeles, California; and ‡Doheny Eye Institute, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Reprint requests: Tara A. McCannel, MD, PhD, Ophthalmic Oncology Center, Stein Eye and Doheny Eye Institutes, UCLA Geffen School of Medicine, Los Angeles, CA 90095; e-mail: [email protected] Paper presented at the Pacific Retina Club, Los Angeles, CA, March 18, 2016. None of the authors have any financial/conflicting interests to disclose. Retinal Cases & Brief Reports: Winter 2017 - Volume 11 - Issue - p S7-S10 doi: 10.1097/ICB.0000000000000383 Buy Metrics AbstractIn Brief Background: To illustrate the evolution of paraneoplastic vitelliform maculopathy over one year using optical coherence tomography. Methods: Observational case report. Results: A 65-year-old man with a history of ocular melanocytosis and choroidal melanoma of the left eye treated with plaque brachytherapy 3 years prior returned for his yearly follow-up visit. The visual acuity in the right eye was 20/20. Subtle thickening of the interdigitation zone layer was noted on optical coherence tomography. Over the following year, multifocal vitelliform detachments developed with progressive enlargement and coalescence of the lesions. Paraneoplastic vitelliform maculopathy developed in the fellow eye of a patient with local recurrence of previously treated choroidal melanoma. Conclusion: Paraneoplastic vitelliform maculopathy may develop in the fellow eye of a patient with local recurrence of their previously treated choroidal melanoma with no clinical evidence of systemic metastasis. A 65-year-old man with a history of treated choroidal melanoma in the left eye 3 years prior presented with enlarging multifocal vitelliform detachments in the right eye. Extraocular extension of the melanoma occurred subsequent to iodine-125 brachytherapy plaque, and the left eye was enucleated. The right eye was diagnosed with paraneoplastic vitelliform maculopathy.