STERILE ENDOPHTHALMITIS AFTER INTRAVITREAL OCRIPLASMIN INJECTION

REPORT OF A SINGLE CASE

Abstract

Purpose: 

To report a case of presumed sterile endophthalmitis after intravitreal ocriplasmin injection.

Methods: 

Observational case report. Review of clinical examination, ocular imaging, and published literature.

Results: 

A 67-year-old woman with early cataracts presented with decreased vision in the left eye related to vitreomacular adhesion. She was treated with intravitreal ocriplasmin injection and developed a severe anterior chamber inflammatory reaction in less than 24 hours after the injection. Inflammation responded completely to topical steroids alone, without topical or intravitreal antibiotics.

Conclusion: 

Patients treated with intravitreal ocriplasmin may develop an acute inflammatory reaction, which can be severe.

In Brief

Sterile endophthalmitis is an uncommon complication after intravitreal injections that can present a significant diagnostic and management challenge. The authors report a case of presumed sterile endophthalmitis after intravitreal ocriplasmin injection. Physicians should be aware that patients treated with intravitreal ocriplasmin may develop an acute inflammatory reaction, which can be severe.