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Yu, Suqin, MD*,†; Bellone, Dennis; Lee, Song Eun, MD§; Yannuzzi, Lawrence A., MD†,¶

Retinal Cases and Brief Reports: April 2015 - Volume 9 - Issue 2 - p 97–101
doi: 10.1097/ICB.0000000000000123
Case Report

Purpose: To describe multimodal imaging findings in a patient with foveal red spot syndrome.

Methods: We report a case of a 57-year-old man with foveal red spot syndrome. Multimodal imaging techniques, including fundus color and red-free photographs, fluorescence angiography (Topcon 50DX; Topcon, Tokyo, Japan), MultiColor scanning laser imaging, spectral domain optical coherence tomography (Spectralis; Heidelberg Engineering, Heidelberg, Germany), swept source optical coherence tomography (DRI OCT-1 Atlantis; Topcon, Tokyo, Japan), adaptive optics (RTX-1; Imagine Eyes, Orsay, France), and microperimetry (MP1 Microperimeter; Nidek Technologies, Padua, Italy), were performed to confirm the diagnosis and determine the anatomical abnormalities related to the disease.

Results: Conventional clinical examination and imaging studies failed to explain the patient's visual dysfunction and this specific macular abnormality. Using advanced ophthalmic technologies, including MultiColor imaging, spectral domain optical coherence tomography with high-density acquisition, swept source optical coherence tomography, adaptive optics, and microperimetry, we identified the nature of the macular manifestation accounting for pathology of the foveal red spot syndrome and his visual dysfunction.

Conclusion: When conventional clinical examination and imaging techniques fail to identify the presence of and visual symptoms in foveal red spot syndrome, advanced technologies may be used to confirm the diagnosis and explain the etiology of the abnormality.

Advanced ophthalmic imaging technology was able to make a diagnosis when conventional examination and imaging techniques failed to correlate with visual dysfunction and foveal red spot syndrome.

*Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, China;

Vitreous-Retina-Macula Consultants of New York, New York, New York;

Manhattan Eye, Ear, and Throat Hospital, New York, New York;

§Edward S. Harkness Eye Institute, Columbia University, New York, New York; and

Columbia University School of Medicine, New York, New York.

Reprint requests: Suqin Yu, MD, Vitreous-Retina-Macula Consultants of New York, 460 Park Avenue, 5th Floor, New York, NY 10022; e-mail:

Supported by K. C. Wong Education Foundation, Hong Kong; LuEsther T. Mertz Retinal Research Center, New York, NY; and The Macular Foundation, Inc.

None of the authors have any financial/conflicting interests to disclose.

© 2015 by Ophthalmic Communications Society, Inc.