Case ReportNEW INSIGHTS INTO ACUTE ANNULAR OUTER RETINOPATHYSeetharam, Shabari S. MD*; Jampol, Lee M. MD†; Gill, Manjot K. MD†Author Information *Arizona Retina and Vitreous Consultants, Phoenix, Arizona; and †Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Reprint requests: Manjot K. Gill, MD, Department of Ophthalmology, Northwestern University Feinberg School of Medicine, 645 N Michigan Avenue, Suite 440, Chicago, IL 60611; e-mail: email@example.com Supported in part by an unrestricted grant to the Department of Ophthalmology from Research to Prevent Blindness, Inc, New York, NY. None of the authors have any conflicting interests to disclose. Retinal Cases and Brief Reports: Winter 2015 - Volume 9 - Issue 1 - p 1-6 doi: 10.1097/ICB.0000000000000070 Buy Metrics AbstractIn Brief Purpose: Acute annular outer retinopathy is a rare entity. There are only a few cases in the world's literature. Our study is the first to describe the spectral domain optical coherence tomography (OCT) findings in the acute presentation of this disease and to follow the disease in convalescence. Methods: This article is a descriptive case report. We used Spectralis OCT to image the transient intraretinal whitening that is initially seen in this disorder, and the OCT changes during follow-up. Results: Our article provides additional information about the natural history of this uncommon disease, and its varied presentation and prognosis. We were able to document the initial white line seen in the acute phase of the disease and correlate it anatomically by using OCT. We found hyperreflectivity in the outer nuclear layer and the Henle fiber layer along with marked atrophy of the outer retina within the white ring. We documented restoration of foveal photoreceptors, which corresponded with visual recovery. We also noted progressive atrophy in areas where the white ring was previously visible. Conclusion: We describe a single case of acute annular outer retinopathy with the corresponding spectral domain OCT findings during the acute phase of the disease and during subsequent follow-up demonstrating progressive atrophy of the outer retina. This may shed insight into possible causation for this rare disease. This report is a description of a single case of acute annular outer retinopathy. The authors were able to document the spectral domain optical coherence tomography findings in the acute and chronic stages of this disease, providing novel insights into this disorder. © 2015 by Ophthalmic Communications Society, Inc.