REPEATED NONINFECTIOUS ENDOPHTHALMITIS AFTER INTRAVITREAL ADMINISTRATION OF BEVACIZUMAB: A REPORT OF TWO CASES

Abstract

Purpose: 

To report on two patients with sterile endophthalmitis recurring twice after intravitreal bevacizumab injection.

Methods: 

Two cases of sterile intraocular inflammation recurring after repeated intravitreal injections of bevacizumab are described, followed by a review of the literature.

Results: 

Two patients presented with painful eyes and decreased vision associated with endophthalmitis several days after intravitreal bevacizumab injection. In both patients, vitreous specimens were sterile. The intraocular inflammation recurred after additional intravitreal injection of bevacizumab that was performed during subsequent follow-up.

Conclusion: 

This is the first report of sterile intraocular inflammation recurring after repeated intravitreal injections of bevacizumab. Awareness of the possible association between bevacizumab administration and sterile endophthalmitis may be warranted.

In Brief

Intravitreal injection of bevacizumab has become common practice in the treatment of neovascular age-related macular degeneration. The authors present two patients with sterile endophthalmitis related to repeated intravitreal bevacizumab injection. In both patients the inflammation recurred after an additional injection of the drug. In both cases the inflammation resolved with treatment, with no long term consequences.