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Emerson, M Vaughn MD*; Saffra, Norman MD; Louis, Les Saint MD; Lin, Amy MD§; Folberg, Robert MD¶**††; Abramson, David H MD‡‡

Retinal Cases and Brief Reports: July 2010 - Volume 4 - Issue 3 - p 243-245
doi: 10.1097/ICB.0b013e3181a59e04
Original Article

Purpose: To report a case of retinoblastoma infiltrating the iris and ciliary body detected on magnetic resonance imaging.

Methods: A retrospective case report with clinical evaluation, diagnostic testing, enucleation, and pathologic description.

Results: A 2-year-old boy presented with hyphema and was noted to have a fluffy whitish iris mass. Retinoblastoma with anterior chamber extension was suggested on magnetic resonance imaging. T2-weighted images demonstrated a hypointense mass with a superficial layer of focal marked hypointensity, consistent with hemorrhage or calcification. Enucleation was performed, and histopathology confirmed retinoblastoma infiltrating the iris and ciliary body. No further treatment was administered, and the patient remains free of associated disease at age 5 years.

Conclusion: Retinoblastoma can invade the iris and ciliary body stroma. The use of magnetic resonance imaging in evaluating cases of anterior segment masses can demonstrate findings suggestive of retinoblastoma.

Anterior segment involvement of retinoblastoma is rare and can lead to confusion in the differential diagnosis. This case illustrates some of the MRI features of retinoblastoma which can assist in narrowing the differential and arriving at the correct diagnosis.

From the *Retina Center, Minneapolis, Minnesota; †Maimonades Hospital, Brooklyn, New York; ‡Corinthian Diagnostic Radiology, New York, New York; §Department of Pathology, University of Illinois Medical Center at Chicago, Chicago, Illinois; Departments of ¶Biomedical Sciences, **Pathology, and ††Ophthalmology, Oakland University William Beaumont School of Medicine, Rochester, Michigan; and ‡‡Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.

None of the authors has any financial interests in the pharmaceuticals or the devices mentioned in this report.

Reprint requests: M. Vaughn Emerson, MD, Retina Center, 710 E. 24th Street, Suite 304, Minneapolis, MN 55404; e-mail:

© 2010 Ophthalmic Communications Society, Inc.