Original ArticlesPURTSCHER-LIKE RETINOPATHY ASSOCIATED WITH PRIMARY HYPEREOSINOPHILIC SYNDROMEGupta, Omesh P. MD, MBA*; Zegere, Eric MD†; Maguire, Joseph I. MD*Author Information From the *Retina Service, Wills Eye Institute, Jefferson Medical College, Philadelphia, Pennsylvania; and the †Hematology/Oncology Service, Lankenau Hospital, Wynnewood, Pennsylvania. Supported by the Heed Ophthalmic Foundation. The authors have no proprietary interest in this study. Reprint requests: Omesh P. Gupta, MD, MBA, Wills Eye Institute, 840 Walnut Street, Suite 1020, Philadelphia, PA 19107; e-mail: [email protected] Retinal Cases & Brief Reports: Spring 2009 - Volume 3 - Issue 2 - p 193-196 doi: 10.1097/ICB.0b013e318162b14d Buy Metrics AbstractIn Brief Purpose: To describe a patient with undiagnosed primary hypereosinophilic syndrome (HES) who presented with Purtscher-like retinopathy and to review the literature. Methods: Observational case report. Patient: A 25-year-old man presented with a 1-week history of bilateral visual blur. Examination revealed multiple peripapillary cotton-wool spots and few intraretinal hemorrhages. Clinical history was obtained and fluorescein angiography, systemic evaluation, laboratory studies, and histopathologic analysis of a bone marrow biopsy specimen were performed. Results: The patient was diagnosed with primary HES. No previous description was found in the literature. Conclusion: HES should be considered in the differential diagnosis of Purtscher retinopathy. This case supports the microembolic theory of Purtscher retinopathy. To the authors’ knowledge, they report the first case of Purtscher-like retinopathy secondary to hypereosinophilic syndrome. Visual acuity improved and retinopathy resolved only after improvement of eosinophilia. © 2009 Ophthalmic Communications Society, Inc.