In Brief:
Validation of Pegasus optical coherence tomography, an artificial intelligence–based software for the automated detection of macula disease from optical coherence tomography scans, is conducted on independent, multicenter data. Five thousand five hundred and eighty-eight volumes spanning multiple populations, device manufacturers, and acquisition sites were assessed. Pegasus optical coherence tomography achieves areas under the curve of the receiver operating characteristic of >98% on age-related macular degeneration, diabetic macular edema, and general anomaly detection.
