In Brief:
Intravitreal tissue plasminogen activator (tPA) is effective for macular edema associated with central retinal vein occlusion. The pretreatment logarithm of the minimum angle of resolution (logMAR) visual acuity (VA), posterior vitreous detachment (PVD) development after tPA, and age were significant prognostic factors. The logMAR VA improvement was 0.335 ± 0.533, and correlated with the PVD development, suggesting that PVD may contribute to a better VA outcome.