Original ArticlesCARCINOMA-ASSOCIATED RETINOPATHY—AN ELECTROPHYSIOLOGICAL AND IMMUNOHISTOCHEMICAL CORRELATIONLINK, BARBARA MD; SCHLÖTZER-SCHREHARDT, URSULA PhD; JÜNEMANN, ANSELM MDAuthor Information From the Department of Ophthalmology, University of Erlangen-Nuernberg, Erlangen, Germany. Reprint requests: Barbara Link, MD, Augenklinik mit Poliklinik, Schwabachanlage 6, D-91054 Erlangen, Germany; e-mail: [email protected] Retina: January 2009 - Volume 29 - Issue 1 - p 69-72 doi: 10.1097/IAE.0b013e3181853d06 Buy Metrics AbstractIn Brief Purpose: To correlate the clinical, electrophysiological, and immunohistochemical findings in patients suffering from carcinoma-associated retinopathy. Methods: Four patients with visual loss were included in this retrospective, observational consecutive case series. Electrophysiology and immunohistochemical analysis were performed to confirm the diagnosis of carcinoma-associated retinopathy. Results: Immunohistochemistry revealed a marked interindividual variability of antibody reactions against different retinal cell layers of individual patients. The electrophysiological changes corresponded to the respective immunohistochemical findings. Conclusion: Carcinoma-associated retinopathy is a heterogeneous disease, caused by different antiretinal antibodies and leading to different electrophysiological abnormalities. Diagnosis should not be delayed as undetected and thus untreated malignancy can be the cause. The clinically and electrophysiologically heterogeneous pattern of carcinoma-associated retinopathy is demonstrated and correlated with the antiretinal antibody profile. © The Ophthalmic Communications Society, Inc.