Original Study: PDF OnlyB-scan ultrasonography of vitreous dynamics during intravitreal administration of antiangiogenicsSánchez-Martínez, Daniel PhD*; Sánchez-López, Sara MD†; Sellés-Navarro, Inmaculada PhD*,‡Author Information *Department of Ophthalmology, Reina Sofia General University Hospital, University of Murcia, Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain †Traumatology Department, Rafael Méndez General University Hospital, Murcia, Spain ‡Spanish Net of Ophthalmic Pathology OFTARED, Institute of Health Carlos III, Madrid, Spain. Corresponding author: Inmaculada Sellés-Navarro, PhD, Departamento de Oftalmología, Facultad de Medicina, Edificio Departamental-LAIB, Planta 5a, Campus Universitario de Ciencias de la Salud, Universidad de Murcia, Avda. Buenavista s/n, 30120 El Palmar (Murcia); e-mail: [email protected] No conflicting relationship exists for any author. Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article. Financial support: This study has been funded by Instituto de Salud Carlos III through the project PI17/00821 (Co-funded by European Regional Development Found “A way to make Europe/Investing in your future”). The sponsor or funding organization had no role in the design or conduct of this research. Retina: March 25, 2021 - Volume - Issue - doi: 10.1097/IAE.0000000000003175 Buy PAP Metrics Abstract Purpose: To study the distribution of angiogenesis inhibitors (anti-VEGF) injected into the vitreous cavity by means of simultaneous ultrasonography. Methods: 332 B-scan ultrasound sequences of 121 eyes from 95 patients were recorded simultaneously to the intravitreal anti-VEGF administration. The dynamics of the injected substance and the presence of reflux were studied, associating them with the presence/absence of total posterior vitreous detachment (t-PVD). Results: Three well-defined patterns were distinguished. Pattern A: the medication penetrates the vitreous in a linear manner until reaching the retina (3.6%, n=12). Pattern B: the medication adopts a globular shape and then moves down reaching the retrohyaloid space (37%, n=123). Pattern C: the medication remains in a globular form (54%, n=180). The pattern was not identified in 17 (5.1%) injections. Pattern A was only observed in vitrectomized eyes. The reflux (7.8%) was exclusive in eyes showing a C pattern. A relationship (p<0.001) was observed between presence/absence of t-PVD, the patterns and the presence of reflux. Conclusions: This study document for the first time the behavior of antiangiogenic medication injected into the vitreous cavity and how its distribution and the presence of reflux is conditioned by the previous state of the vitreous body. © 2021 by Ophthalmic Communications Society, Inc.