TIMING AND OUTCOME OF SURGERY FOR PERSISTENT MACULAR HOLEPatel, Rutul, MD; Gopalakrishnan, Mahesh, MD; Giridhar, Anantharaman, MDRETINA: February 2019 - Volume 39 - Issue 2 - p 314–318 doi: 10.1097/IAE.0000000000001939 Original Study Abstract In Brief Author InformationAuthors Article MetricsMetrics Purpose: To evaluate the efficacy and optimum timing for resurgery in case of persistent macular hole (MH). Methods: Twenty-five eyes of 25 patients who underwent fluid–air exchange with intravitreal C3F8 for persistent MH after vitrectomy + internal limiting membrane peeling + SF6 were included in the study. Best-corrected visual acuity, optical coherence tomography features including base diameter and configuration of MH, and time duration between the two surgeries were noted. Results: Patients who underwent resurgery within 3 months of the first surgery had better anatomical closure rate compared with those who underwent resurgery after 3 months (P < 0.05). Significant improvement was seen in best-corrected visual acuity in eyes with closed MH. Eyes having MH with irregular edges on optical coherence tomography had better anatomical closure rates compared with the eyes having MH with round edges. Conclusion: Patients undergoing repeat gas injection within 3 months of the primary surgery for persistent MH have better anatomical closure rates compared with late intervention. This study evaluates the optimum timing for resurgery for persistent macular hole. There was a significantly better anatomical success noted in patients who were operated within 3 months of primary surgery compared with those who were operated after 3 months of primary surgery. Vitreo-retina Department, Giridhar Eye Institute, Cochin, India Reprint requests: Rutul Patel, MD, Giridhar Eye Institute, Ponneth Temple Road, Kadavanthra, Cochin 682020, Kerala, India; e-mail: email@example.com None of the authors has any financial/conflicting interests to disclose. © 2019 by Ophthalmic Communications Society, Inc.