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Tognetto, Daniele, MD*; Pastore, Marco R., MD*; Cirigliano, Gabriella, MD*; D'Aloisio, Rossella, MD*; Borelli, Massimo, PhD; De Giacinto, Chiara, MD*

doi: 10.1097/IAE.0000000000001933
Original Study

Purpose: To investigate long-term intraocular pressure trends after uncomplicated pars plana vitrectomy for idiopathic epiretinal membrane.

Methods: Three hundred and sixty-eight eyes of 368 consecutive patients were enrolled. Changes in intraocular pressure 1, 3, 6, and 12 months after surgery and during the final follow-up visit were evaluated in vitrectomized eyes and nonvitrectomized fellow eyes.

Results: The median follow-up period was 36 months (range 12–92 months). Longitudinal data analysis evidenced a 2.5-mmHg (2.2 mmHg; 2.7 mmHg, 95% confidence interval) statistically significant difference in intraocular pressure 30 days after surgery between treated and fellow untreated eyes, gradually recovering to a not significant 0.2-mmHg (−0.1 mmHg; 0.4 mmHg, 95% confidence interval) difference within 26 months. The incidence of late-onset ocular hypertension was 5.7% (21 over 347, 2%; 12%, 95% confidence interval) without difference between the treated eyes and the group control. No significant difference in the incidence of late-onset ocular hypertension and sex, lens status, or gauge of vitrectomy instruments was detected. Only patient's age was significantly higher (mean difference 4.2 years; 0.1–8.0 years, Monte Carlo, 95% confidence interval) in those who developed late-onset ocular hypertension in the vitrectomized eye.

Conclusion: Uncomplicated pars plana vitrectomy for idiopathic epiretinal membrane seems not to increase the risk of late-onset ocular hypertension or open-angle glaucoma development.

The authors’ analysis of data from 368 consecutive eligible eyes with idiopathic epiretinal membrane after uncomplicated pars plana vitrectomy revealed no increased risk of late-onset ocular hypertension or open-angle glaucoma development.

*Eye Clinic, Department of Medical Surgical Sciences and Health, University of Trieste, Ospedale Maggiore, Trieste, Italy; and

Department of Mathematics and Computer Science, University of Trieste, Trieste, Italy.

Reprint requests: Marco R. Pastore, MD, University Eye Clinic of Trieste, Ospedale Maggiore, Piazza Ospitale 1, 34129 Trieste, Italy; e-mail:

Presented in part at 16th EURETINA Congress, Copenhagen, Denmark, November 11, 2016.

None of the authors has any financial/conflicting interests to disclose.

© 2019 by Ophthalmic Communications Society, Inc.