To assess the reproducibility of confocal white-light color fundus photography (C-CFP) for the measurement of retinal pigment epithelial atrophy in comparison with confocal blue-light fundus autofluorescence (FAF) imaging and flash color fundus photography (F-CFP).
In this prospective study, eyes with age-related macular degeneration associated with evidence of retinal pigment epithelial atrophy were imaged by C-CFP, F-CFP, and FAF. Intergrader reproducibility of each modality was assessed by comparison of manual measurements by two expert graders.
The mean areas of atrophy measured by the 2 graders were 6.67 ± 6.39, 6.35 ± 6.13, and 6.07 ± 5.48 mm2 for FAF, C-CFP, and F-CFP, respectively. The mean differences between the 2 graders in measuring the atrophic areas were 0.52, 0.69, and 1.62 mm2 for the three modalities. The intraclass correlation coefficient between the 2 graders for each modality was 0.998, 0.990, and 0.961, respectively.
Measurements of atrophy from C-CFP were similar to those obtained by FAF and F-CFP. The grading reproducibility for C-CFP, however, was better than that for F-CFP and approached the level of FAF imaging. The use of C-CFP as a tool for quantitatively monitoring atrophic age-related macular degeneration lesions warrants further study, particularly in the context of clinical trials.
In this prospective study, we assessed the reproducibility of confocal white-light color fundus photography in measurement of age-related macular degeneration atrophic lesions, which turned out to be better than that of flash color fundus photography and approached the level of confocal fundus autofluorescence imaging.
*Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California;
†Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California;
‡Department of ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;
§Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; and
¶Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Reprint requests: SriniVas R. Sadda, MD, Doheny Image Reading Center, Doheny Eye Institute, 1350 San Pablo Street, DVRC211, Los Angeles, CA 90033; e-mail: firstname.lastname@example.org
None of the authors has any financial/conflicting interests to disclose.