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Ersoz, M. Giray, MD; Arf, Serra, MD; Hocaoglu, Mumin, MD, FEBO; Sayman Muslubas, Isil, MD, FEBO; Karacorlu, Murat, MD, MSc, FEBO

doi: 10.1097/IAE.0000000000001773
Original Study

Purpose: To compare choroidal hyperpermeability and vessel density between eyes with central serous chorioretinopathy (CSC), those with pachychoroid pigment epitheliopathy (PPE) and those with uncomplicated pachychoroid (UCP).

Methods: We retrospectively reviewed indocyanine green angiography images of 60 patients with unilateral active CSC who had PPE (36 eyes) or UCP (24 eyes) in their fellow eyes. We used color thresholding of indocyanine green angiography images to determine choroidal vessel density.

Results: The mean choroidal thickness of eyes with CSC was greater than that of eyes with PPE or UCP, but this difference was not statistically significant (P = 0.46). There was no significant difference between the PPE (92%) and CSC (93%) groups regarding choroidal hyperpermeability (P = 0.76), but both of these groups had higher choroidal permeability than the UCP group (50%) (both P < 0.001). In 30 (90%) of 33 eyes with PPE who had choroidal hyperpermeability, retinal pigment epithelium alterations were in the region of hyperpermeability. Choroidal vessel density did not differ between the PPE and UCP groups (P = 0.57).

Conclusion: Pachychoroid pigment epitheliopathy is forme fruste of CSC. There is no difference between complicated and UCP regarding subfoveal choroidal thickness and choroidal vessel density. The main difference between these groups is choroidal hyperpermeability.

Choroidal thickness and choroidal vessel density do not differ between complicated and uncomplicated pachychoroid conditions. Choroidal hyperpermeability is the main difference between these conditions and may cause the retina pigment epithelium alterations seen in pachychoroid pigment epitheliopathy.

Istanbul Retina Institute, Istanbul, Turkey.

Reprint requests: Murat Karacorlu, MD, MSc, FEBO, Istanbul Retina Institute, Hakki Yeten Cad. Unimed Center No: 19/7 Fulya – Şişli, Istanbul 34349, Turkey; e-mail:

None of the authors has any financial/conflicting interests to disclose.

The authors had full access to all the data in the study and take full responsibility for the integrity and the accuracy of the data as well as the decision to submit for publication. All authors approved the manuscript and its submission.

© 2018 by Ophthalmic Communications Society, Inc.