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Forlini, Matteo, MD*; Date, Purva, DNB, FVRS; Ferrari, Luisa Micelli, MD; Lorusso, Massimo, MD; Lecce, Gabriella, MD*; Verdina, Tommaso, MD*; Neri, Giovanni, MD*; Benatti, Caterina, MD*; Rossini, Paolo, MD§; Bratu, Adriana, MD§; D'Eliseo, Domenico, MD§; Ferrari, Tommaso Micelli, MD; Cavallini, Gian Maria, MD*

doi: 10.1097/IAE.0000000000001775
Original Study

Purpose: To determine whether internal limiting membrane (ILM) peeling during pars plana vitrectomy for rhegmatogenous retinal detachment reduces the incidence of epiretinal membrane (ERM) formation.

Methods: In this retrospective study, preoperative, intraoperative, and postoperative data from all eyes undergoing pars plana vitrectomy for rhegmatogenous retinal detachment between January 2007 and December 2013 was analyzed. All cases with at least 1-year of follow-up were included. Data collection included vision, intraoperative complications, occurrence of ERM, and spectral domain optical coherence tomography characteristics. The OCTs were retrieved for all eyes and were graded by a single masked grader.

Results: Out of 159 eyes recruited, ILM peeling was done in 78 eyes (49%). Overall occurrence of ERM was 20%. Seven eyes (9%) in ILM peeling group and 25 eyes in the non-ILM peeling group (31%) showed ERM (P = 0.001). Postoperative vision was significantly better in eyes that had ILM peeling (0.48 ± 0.4 logarithm of the minimum angle of resolution [20/63] vs. 0.77 ± 0.6 logarithm of the minimum angle of resolution [20/125], P = 0.003). In multivariable models adjusting for type of tamponade, ILM peeling reduced the likelihood of ERM formation by 75% (P = 0.01).

Conclusion: Internal limiting membrane peeling during pars plana vitrectomy for rhegmatogenous retinal detachment significantly reduces ERM formation in the postoperative period and is associated with better visual and anatomical outcomes.

A comparative study to assess outcomes of vitrectomy with and without internal limiting membrane peeling about formation of macular pucker.

*Institute of Ophthalmology, University of Modena and Reggio Emilia, Modena, Italy;

Vitreoretina Department, Aditya Jyot Eye Hospital, Wadala, Mumbai, India;

Department of Ophthalmology, “F. Miulli” Hospital, Acquaviva delle Fonti-Bari, Italy; and

§Department of Ophthalmology, “S. Maria delle Croci” Hospital, Ravenna, Italy.

Reprint requests: Purva Date, DNB, FVRS, Department of Vitreo-Retina, Aditya Jyot Eye Hospital, 502, Shiv sahyadri, Plot number 5, sector 42 Nerul (W), Navi Mumbai, Maharashtra, India, 400706; e-mail:

None of the authors have any financial/conflicting interests to disclose.

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© 2018 by Ophthalmic Communications Society, Inc.