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Pellegrini, Marco, MD*; Corvi, Federico, MD*; Say, Emil A. T., MD; Shields, Carol L., MD; Staurenghi, Giovanni, MD, FARVO*

doi: 10.1097/IAE.0000000000001730
Original Study

Purpose: To describe the imaging features of choroidal neovascularization (CNV) associated with choroidal nevus using optical coherence tomography angiography (OCT-A) imaging.

Methods: Retrospective observational case series. Patients with CNV secondary to choroidal nevus underwent full imaging examination including fundus photography, fluorescein angiography, indocyanine green angiography, spectral domain OCT, and OCT-A. The OCT-A features were analyzed and correlated with conventional angiography findings and spectral domain OCT.

Results: There were 11 eyes from 11 patients (6 men and 5 women, mean age of 65 ± 20.4 years) included in the analysis. Fluorescein angiography and indocyanine green angiography disclosed CNV in 90% and 83%, respectively. Optical coherence tomography angiography displayed CNV network in 11 eyes (100%) and the pattern was classified as “sea-fan” in 8 (73%) and “long filamentous linear vessels” in 3 (27%) eyes. Distinct from CNV, intrinsic vasculature within the nevus was observed in six eyes (55%), corresponding to those with chronic retinal pigment epithelium changes.

Conclusion: Optical coherence tomography angiography is a useful imaging technique to disclose CNV associated with choroidal nevus. Despite the presence of intraretinal or subretinal fluid and hemorrhage, OCT-A revealed the CNV in all cases, results noninferior to indocyanine green angiography. This imaging modality can be useful for analysis of long-standing nevi with related exudation.

Optical coherence tomography angiography of 11 eyes with choroidal nevus and overlying choroidal neovascularization disclosed neovascular network in all cases and additional intrinsic vasculature with the nevus in 6 eyes.

*Eye Clinic, Department of Biomedical and Clinical Science “Luigi Sacco,” Luigi Sacco Hospital, University of Milan, Milan, Italy; and

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Reprint requests: Marco Pellegrini, MD, Eye Clinic, Department of Biomedical and Clinical Sciences “Luigi Sacco,” Luigi Sacco Hospital, University of Milan, 4th floor, Building #51, Milan, Italy; 20157 e-mail:

M. Pellegrini received lecture fees from Optovue Inc, G. Staurenghi received grants and personal fees from Optovue Inc, Heidelberg Engineering, Zeiss Meditec, Nidek and Centervue. None of the remaining authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.