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Cho, Han, Joo, MD; Hwang, Hyun, Ji, MD; Kim, Hyoung, Seok, MD; Lee, Dong, Won, MD; Kim, Chul, Gu, MD; Kim, Byoung, Yeop, MD; Kim, Jong, Woo, MD, PhD

doi: 10.1097/IAE.0000000000001668
Original Study

Purpose: To evaluate the incidence of pseudophakic macular edema (PME) in eyes with a history of retinal vein occlusion before cataract surgery and to identify any associated risk factors.

Methods: The records of 21,332 eyes that underwent cataract surgery were retrospectively reviewed. Eyes that had retinal vein occlusion preoperatively with no evidence of macular pathology on optical coherence tomography at the time of surgery and no macular edema treatment at least 6 months before surgery were included. Eyes with diabetes or diabetic retinopathy, those with a history of previous intraocular surgery or with intraoperative complications, and those administered glaucoma and nonsteroidal antiinflammatory eye drops were excluded.

Results: Pseudophakic macular edema developed in 31 (27.4%) of 113 eyes within 3 months of cataract surgery. Mean visual acuity for eyes with PME (0.48 logarithm of the minimum angle of resolution [logMAR; 20/60 Snellen equivalent]) at 3 months after surgery was significantly worse than that for eyes without PME (0.28 logMAR; 20/38, P = 0.020). However, there was no significant difference in the visual acuity between the 2 groups 6 months after the surgery. Taking into consideration various baseline factors, a history of previous treatment of macular edema was significantly associated with an increased risk of PME (odds ratio, 11.022; 95% confidence interval, 7.258–17.712; P = 0.009). A higher number of intravitreal injections used to treat macular edema also significantly increased the risk of PME (odds ratio, 1.902; 95% confidence interval, 1.032–4.227; P = 0.031).

Conclusion: Pseudophakic macular edema frequently developed after phacoemulsification cataract surgery in patients with a history of retinal vein occlusion. The risk of PME further increased when the patient had undergone macular edema treatment and had a higher prevalence of intravitreal injection treatment.

In this retrospective study, pseudophakic macular edema frequently developed in patients with retinal vein occlusion history (27.4%, 31 of 113 eyes). The risk of pseudophakic macular edema development was associated with a history of macular edema and the number of previous intravitreal injections.

Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, South Korea.

Reprint requests: Han Joo Cho, MD, Kim's Eye Hospital, 156, 4ga, Yeoungdeungpo-dong, Yeoungdeungpo-gu, Seoul 07301, South Korea; e-mail:

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.