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Palkovits, Stefan MD, PhD*; Seidel, Gerald MD*; Pertl, Laura MD*; Malle, Eva M. MD*; Hausberger, Silke MD*; Makk, Johanna MD*; Singer, Christoph*; Osterholt, Julia*; Herzog, Sereina A. PhD; Haas, Anton MD*; Weger, Martin MD*

doi: 10.1097/IAE.0000000000001480
Original Study

Purpose: To evaluate the effect of intravitreal bevacizumab on the macular choroidal volume and the subfoveal choroidal thickness in treatment naïve eyes with exudative age-related macular degeneration.

Methods: The macular choroidal volume and the subfoveal choroidal thickness were measured using enhanced depth imaging optical coherence tomography. After a screening examination, each patient received 3 monthly intravitreal injections of 1.25 mg bevacizumab. One month after the third injection was a final assessment.

Results: Forty-seven patients with a mean age of 80 ± 6.4 years were included. The macular choroidal volume decreased significantly from median 4.1 mm3 (interquartile range 3.4–5.9) to median 3.9 mm3 (interquartile range 3.1–5.6) between the baseline and final examination (difference −0.46 mm3, 95% confidence interval: −0.57 to 0.35, P < 0.001). Similarly, subfoveal choroidal thickness had decreased from 157.0 μm (interquartile range 116.0–244.5) at baseline to 139.0 μm (interquartile range 102.5–212.0) at the final examination (P < 0.001). Both parameters macular choroidal volume at baseline and subfoveal choroidal thickness at baseline were not associated with the response to treatment.

Conclusion: The macular choroidal volume and the subfoveal choroidal thickness decreased significantly after 3 monthly bevacizumab injections for exudative age-related macular degeneration.

Supplemental Digital Content is Available in the Text.The present study evaluated the effect of three consecutive intravitreal bevacizumab injections on the choroidal volume and the choroidal thickness in patients with exudative age-related macular degeneration. Forty-seven patients were included in this study. Its findings showed a significant reduction in choroidal volume and choroidal thickness.

*Department of Ophthalmology, Medical University of Graz, Graz, Austria; and

Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.

Reprint requests: Stefan Palkovits, MD, PhD, Department of Ophthalmology, Medical University of Graz, Auenbruggerplatz 4, A-8010 Graz, Austria; e-mail:

None of the authors has any financial/conflicting interests to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (

© 2017 by Ophthalmic Communications Society, Inc.