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Arya, Malvika, BS*; Rebhun, Carl B., BA*; Cole, Emily D., BS*; Sabrosa, Almyr S., MD*,†; Arcos-Villegas, Gabriel, MD; Louzada, Ricardo N., MD, PhD*,§; Novais, Eduardo A., MD, PhD*,¶; Lane, Mark, MD*,**; Dang, Sabin, MD*; Ávila, Marcos, MD, PhD††; Witkin, André J., MD*; Baumal, Caroline R., MD*; Duker, Jay S., MD*; Waheed, Nadia K., MD, MPH*

doi: 10.1097/IAE.0000000000002241
Original Study: PDF Only

Purpose: To compare the sensitivity of detection and the measured size of choroidal neovascularization (CNV) on two commercially available spectral domain optical coherence tomography angiography (OCTA) devices, the Optovue RTVue XR Avanti with AngioVue and the Zeiss Cirrus HD-OCT with AngioPlex.

Methods: Patients with CNV lesions were imaged consecutively on both OCTA devices on the same day of their visit. 3 × 3 mm and 6 × 6 mm scans centered at the fovea were obtained. Two independent masked readers evaluated the OCTA images for CNV identification and its area measurements.

Results: No significant differences were observed between the 2 OCTA devices in CNV area measurements on their 3 × 3 mm and 6 × 6 mm scans. However, there was suboptimal performance of their automated segmentation algorithms as compared to manually adjusted segmentation for visualizing CNV lesions.

Conclusion: There was no significant difference in the size of the CNV lesion as measured on either commercially available spectral domain OCTA device. Both devices were comparable in their detection of CNV lesions on manual adjustment of segmentation lines. However, their automated segmentation algorithms need improvement to allow for accurate measurement of CNV lesions for routine clinical application.

Spectral domain Optovue RTVue XR Avanti and Zeiss Cirrus HD optical coherence tomography angiography devices were found comparable in the identification and measurement of choroidal neovascularization lesions. Manually adjusted segmentation was found superior during image analysis in comparison with automated segmentation. Automated segmentation algorithms need improvement for accurate assessment of choroidal neovascularization lesions in clinical practice.

*New England Eye Center, Tufts Medical Center, Boston, Massachusetts;

Institute of Ophthalmology, Rio de Janeiro, Brazil;

Hospital Clinico San Carlos, Madrid, Spain;

§Federal University of Goiás, Goiânia, Brazil;

Federal University of São Paulo, School of Medicine, São Paulo, Brazil;

**Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; and

††Federal University of Goiás, Goiânia, Goiás, Brazil.

Reprint requests: Nadia K. Waheed, MD, MPH, Boston Image Reading Center, New England Eye Center at Tufts Medical Center, 260 Tremont Street, Biewend Building, 9–11th Floor, Boston, MA 02116; e-mail:

Supported in part by a grant from the Macula Vision Research Foundation and the Massachusetts Lions Club. R. N. Louzada and E. A. Novais are researchers supported by CAPES Foundation, Ministry of Education of Brazil, Brasília, DF, Brazil.

Caroline R. Baumal is a speaker for Optovue and Carl Zeiss Meditech, and has served on the advisory board for Genentech. Jay S. Duker is a consultant for and receives research support from Carl Zeiss Meditec and Optovue. Nadia K. Waheed is a consultant for Optovue, and receives research support from Carl Zeiss Meditec, Topcon Medical Systems, and Nidek Medical Products.

© 2018 by Ophthalmic Communications Society, Inc.