Institutional members access full text with Ovid®

Share this article on:

TREFOIL FACTOR FAMILY 1 EXPRESSION CORRELATES WITH CLINICAL OUTCOME IN PATIENTS WITH RETINOBLASTOMA

Busch, Maike, PhD*; Metz, Klaus, MD; Beier, Manfred; Biewald, Eva, MD§; Dünker, Nicole, PhD*

doi: 10.1097/IAE.0000000000001881
Original Study: PDF Only

Purpose: Correlation of trefoil factor family 1 (TFF1) expression in retinoblastoma tumors with different clinical parameters to evaluate a potential involvement of TFF1 in tumor development and progression.

Methods: A representative cohort of 59 enucleated eyes from individual patients with retinoblastoma was analyzed for its TFF1 expression profile by immuno staining and real-time PCR. Trefoil factor family 1 expression was correlated with demographics, laterality, tumor-node-metastasis stage, International Classification of Retinoblastoma, tumor differentiation level, and treatment.

Results: According to our analysis, increased TFF1 expression significantly correlates with unilateral tumors diagnosed in older children and with poorly differentiated tumors and higher tumor-node-metastasis stages.

Conclusion: This retrospective study reveals that unilateral tumors at a higher clinical tumor-node-metastasis stage and poorly differentiated tumor cells express significantly higher levels of TFF1 than those of differentiated tumors at lower tumor-node-metastasis stages. Besides, TFF1 expression correlates with the age of the patients at the time of tumor diagnosis. Our data indicate that TFF1 expression levels are potentially useful additional markers in the classification of tumor staging and prognosis of patients with retinoblastoma.

Trefoil family factor 1 expression levels in retinoblastoma correlate with laterality, age of diagnosis, differentiation level, and tumor-node-metastasis stage, indicating its potential involvement in the development and progression of this childhood tumor.

*Department of Neuroanatomy, Institute of Anatomy II, Medical Faculty, University of Duisburg-Essen, Essen, Germany;

Institute of Pathology, Medical Faculty, University of Duisburg-Essen, Essen, Germany;

Institute of Human Genetics, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany; and

§Department of Ophthalmology, Children's Hospital, University of Duisburg-Essen, Essen, Germany.

Reprint requests: Maike Busch, PhD, Department of Neuroanatomy, Institute of Anatomy II, Medical Faculty, University of Duisburg-Essen, Essen, Germany 45147; e-mail: maike.busch@uk-essen.de

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.