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Sancak, Selim, MD*; Toptan, Handan H., MD*; Gokmen Yildirim, Tulin, MD*; Karatekin, Guner, MD*; Ovali, Fahri, MD

doi: 10.1097/IAE.0000000000002028
Original Study: PDF Only

Purpose: To study the association between thrombocytopenia and retinopathy of prematurity (ROP).

Methods: The case-control study was conducted on preterm newborns with ROP between January 2011 and January 2014, retrospectively. The patients were assigned into two groups: Cases required intervention and controls developed no or Stage I ROP.

Results: Eighty-one premature infants with Type I ROP were enrolled to the study with a mean gestational age of 27.6 ± 2.1 (range: 24–32) weeks and birth weight of 993 ± 292 (range: 560–1,930) g. Mean follow-up time was 38.3 ± 2.7 weeks (min: 32 and max: 46 weeks). Cases were individually matched to a set of controls (1:1 ratio). Thrombocytopenia (<150.000/mm3) was seen in 58 (71.6%) of the cases with Type I ROP, whereas only 17 (21%) of the controls had thrombocytopenia (P < 0.001). Logistic regression analysis showed that bronchopulmonary dysplasia and thrombocytopenia were significantly associated with Type I ROP (relative risk [95% confidence interval]: 4.19 [1.47–12] and 6.69 [2.83–15.9], respectively). The thrombocytopenia ratio (P = 0.073), thrombocytopenia 1 week before intervention (P = 0.076) and platelet transfusion ratio (P = 0.062) tended to be higher in Zone I ROP compared with Zone II ROP.

Conclusion: In our study, there was a significant association between thrombocytopenia and Type I ROP.

Thrombocytopenia is frequently seen in very low birth weight infants and is an important morbidity factor. Thrombocytopenia is a significant risk factor in the preterm neonates for retinopathy of prematurity.

*Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, TR; and

Neonatal Intensive Care Unit, Medeniyet University, Istanbul, TR.

Reprint requests: Selim Sancak, MD, Izzet Baysal Government Hospital, Sağlık mahallesi, Şehitler caddesi, 14300 Merkez/Bolu, Türkiye, Bolu, Turkey; e-mail:

None of the authors has any financial/conflicting interests to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (

The terms of this arrangement have been reviewed and approved by Zeynep Kamil Maternity and Children's Training and Research Hospital.

© 2019 by Ophthalmic Communications Society, Inc.