To study the association between thrombocytopenia and retinopathy of prematurity (ROP).
The case-control study was conducted on preterm newborns with ROP between January 2011 and January 2014, retrospectively. The patients were assigned into two groups: Cases required intervention and controls developed no or Stage I ROP.
Eighty-one premature infants with Type I ROP were enrolled to the study with a mean gestational age of 27.6 ± 2.1 (range: 24–32) weeks and birth weight of 993 ± 292 (range: 560–1,930) g. Mean follow-up time was 38.3 ± 2.7 weeks (min: 32 and max: 46 weeks). Cases were individually matched to a set of controls (1:1 ratio). Thrombocytopenia (<150.000/mm3) was seen in 58 (71.6%) of the cases with Type I ROP, whereas only 17 (21%) of the controls had thrombocytopenia (P < 0.001). Logistic regression analysis showed that bronchopulmonary dysplasia and thrombocytopenia were significantly associated with Type I ROP (relative risk [95% confidence interval]: 4.19 [1.47–12] and 6.69 [2.83–15.9], respectively). The thrombocytopenia ratio (P = 0.073), thrombocytopenia 1 week before intervention (P = 0.076) and platelet transfusion ratio (P = 0.062) tended to be higher in Zone I ROP compared with Zone II ROP.
In our study, there was a significant association between thrombocytopenia and Type I ROP.
Thrombocytopenia is frequently seen in very low birth weight infants and is an important morbidity factor. Thrombocytopenia is a significant risk factor in the preterm neonates for retinopathy of prematurity.
*Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, TR; and
†Neonatal Intensive Care Unit, Medeniyet University, Istanbul, TR.
Reprint requests: Selim Sancak, MD, Izzet Baysal Government Hospital, Sağlık mahallesi, Şehitler caddesi, 14300 Merkez/Bolu, Türkiye, Bolu, Turkey; e-mail: firstname.lastname@example.org
None of the authors has any financial/conflicting interests to disclose.
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