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RETINAL ARTERIAL DILATION IS IMPAIRED IN EYES WITH DRUSEN AND RETICULAR PSEUDODRUSEN

Rabiolo, Alessandro, MD*; Benatti, Lucia, MD*; Tomasso, Livia, MD*; Zucchiatti, Ilaria, MD*; Gelormini, Francesco*; Casaluci, Marco*; Querques, Lea, MD*; Sacconi, Riccardo, MD*,†; Bandello, Francesco, MD, FEBO*; Querques, Giuseppe, MD, PhD*

doi: 10.1097/IAE.0000000000002283
Original Study: PDF Only

Purpose: To analyze static characteristics and dynamic functionality of retinal vessels in eyes with drusen and reticular pseudodrusen (RPD) using dynamic vessel analyzer.

Methods: Patients with clinical diagnosis of isolated RPD or medium-large drusen and healthy controls were enrolled in the study between July 2016 and May 2018. Participants underwent complete ophthalmologic examination, including enhanced depth imaging structural optical coherence tomography, dynamic retinal vessel analysis, and static retinal vessel analysis.

Results: Twenty-eight eyes of 23 patients with drusen (9 men, mean age 77 ± 6 years), 22 eyes of 16 patients with RPD (7 men, mean age: 76 ± 6 years), and 22 eyes of 22 control subjects (11 men, mean age of 75 ± 6 years) were enrolled. Static retinal vessel analysis did not show any significant difference between the three groups for the central retinal artery equivalent (P = 0.11), the central retinal vein equivalent (P = 0.27), and the arteriovenous ratio (P = 0.30). Dynamic vessel analysis showed significantly reduced arterial dilation in eyes with drusen (P = 0.0001) and RPD (P = 0.015) compared with control subjects. No significant difference was seen between drusen and RPD groups (P = 0.32). Dynamic vessel analysis of retinal veins showed no differences between the three groups (P = 0.10).

Conclusion: Dynamic vessel analysis in eyes with drusen and RPD revealed an impaired retinal arterial dilation in response to flicker light stimulation, which further supports the relationship between cardiovascular risk and age-related macular degeneration.

In this prospective, cross-sectional study, we compared the static and dynamic functionality of retinal vessels in patients with reticular pseudodrusen, soft drusen, and healthy controls. Dynamic vessel analysis in eyes with drusen and reticular pseudodrusen revealed an impaired retinal arterial dilation in response to flicker light stimulation, which further supports the relationship between cardiovascular risk and age-related macular degeneration.

*Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy; and

Department of Neurological and Movement Sciences, Eye Clinic, University of Verona, Verona, Italy.

Reprint requests: Giuseppe Querques, MD, PhD, Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita Salute San Raffaele, Via Olgettina 60, Milan, 20132, Italy; e-mail: giuseppe.querques@hotmail.it

G. Querques is consultant for: Alimera Sciences (Alpharetta, GA), Allergan Inc (Irvine, CA), Bayer Schering-Pharma (Berlin, Germany), Heidelberg (Germany), Novartis (Basel, Switzerland), Sandoz (Berlin, Germany), and Zeiss (Dublin). Francesco Bandello has the following disclosures: ALLERGAN (S), ALIMERA (S), BAYER (S), FARMILA-THEA (S), SCHERING PHARMA (S), SANOFI-AVENTIS (S), NOVAGALI (S), PHARMA (S), HOFFMANN-LA ROCHE (S), GENENTECH (S), and NOVARTIS (S).

© 2018 by Ophthalmic Communications Society, Inc.