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REPEATABILITY OF CHOROIDAL THICKNESS MEASUREMENTS ASSESSED WITH SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY IN HEALTHY AND DIABETIC INDIVIDUALS

Abadía, Beatriz, MD, PhD*; Calvo, Pilar, MD, PhD*,†; Bartol-Puyal, Francisco, MD*; Verdes, Guayente, MD, PhD; Suñén, Inés, MD; Ferreras, Antonio, MD, PhD*,†

doi: 10.1097/IAE.0000000000002022
Original Study: PDF Only

Purpose: To assess the intrasession repeatability of choroidal thickness measurements obtained using swept-source optical coherence tomography in Type 2 diabetic (T2D) patients and healthy controls.

Methods: This was a single-center, prospective, observational, cross-sectional study with consecutive inclusion of 33 healthy subjects and 43 T2D patients. Subjects underwent three consecutive swept-source optical coherence tomography scans in a single session. After automatic delineation of the choroid, subfoveal choroidal thickness, and thickness at 500-μm intervals up to 2,500 μm nasal and temporal from the fovea were measured using the software caliper by the same operator. Intraclass correlation coefficients (ICCs), coefficients of variation, and test-retest variability were calculated.

Results: Mean subfoveal choroidal thickness in healthy subjects and in T2D patients was 229.97 ± 79.9 and 192.67 ± 74.3 μm, respectively (P = 0.013). All intrasession intraclass correlation coefficients were higher than 0.95 and 0.99, respectively. Coefficients of variations were less than 4.4% and 1.8%, respectively. Test-retest variability ranged from 0.76 μm to 11.12 μm and 0.64 μm to 6.29 μm, respectively. No significant differences were found in the intrasession repeatability of any choroidal measurement between healthy subjects and T2D patients.

Conclusion: Swept-source optical coherence tomography provided excellent intrasession repeatability of choroidal thickness measurements in healthy subjects and T2D patients.

Swept-source optical coherence tomography generated good layer segmentation, leading to low variability of macular choroidal thickness measurements. Macular choroidal thickness was reduced in patients with Type 2 diabetes mellitus.

*Department of Ophthalmology, IIS-Aragon, Miguel Servet University Hospital, Zaragoza, Spain;

Department of Surgery, Gynecology and Obstetrics, University of Zaragoza, Zaragoza, Spain; and

Endocrinology Department, Hospital de Alcañiz, Teruel, Spain.

Reprint requests: Antonio Ferreras, MD, PhD, Department of Ophthalmology, Miguel Servet University Hospital, Isabel la Catolica, 1-3 50009 Zaragoza, Spain; e-mail: aferreras@msn.com

None of the authors has any financial/conflicting interests to disclose.

© 2018 by Ophthalmic Communications Society, Inc.