To determine predictive factors of proliferative vitreoretinopathy (PVR) formation after uncomplicated primary retinal detachment repair.
Retrospective, single-center, case–control study of 74 consecutive patients with (37 eyes) and without (37 eyes) PVR formation after undergoing uncomplicated primary surgery for retinal detachment repair. Logistic regression was used to assess factors associated with PVR formation.
Retinal detachment involving the macula was 4.2 times (adjusted odds ratio; 95% confidence interval, 1.4–12.9; P = 0.0119) more likely to have PVR formation compared with those without. Patients who were current or former smokers were 3.6 times (adjusted odds ratio; 95% confidence interval, 1.1–11.7; P = 0.0352) more likely to have PVR formation compared with nonsmokers. Compared with 25-gauge (g) vitrectomy, larger gauge vitrectomy (20 g or 23 g) was 3.6 times (adjusted odds ratio; 95% confidence interval, 1.2–11.3; P = 0.0276) more likely to have PVR formation. Duration of retinal detachment symptoms, high myopia, lens status, lattice degeneration, location of retinal break, number of retinal breaks, and surgical technique (e.g., scleral buckle with or without vitrectomy versus vitrectomy alone) were not found to be predictive of PVR formation.
Cigarette smoking and macular involvement are significant risk factors predictive of PVR formation after uncomplicated primary retinal detachment repair.
Cigarette smoking and retinal detachments involving the macula are identified as risk factors for proliferative vitreoretinopathy formation after uncomplicated retinal detachment repair. Findings of this study enable clinicians to identify patients who may be at the higher risk of proliferative vitreoretinopathy formation after uncomplicated repair.
*Department of Ophthalmology, Weill Cornell Medical College, New York City, New York;
†Retina Consultants of Southern California, Redlands, California;
‡VitreoRetinal Surgery PA, Minneapolis, Minnesota; and
§University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Reprint requests: David R. P. Almeida, MD, MBA, PhD, Surgery and Diseases of the Retina, Vitreous & Macula Metrolina Eye Associates, 630 Comfort Lane, Suite E, Monroe, NC 28112; e-mail: firstname.lastname@example.org
None of the authors has any financial/conflicting interests to disclose.