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PERIPAPILLARY NEUROVASCULAR COUPLING IN THE EARLY STAGES OF DIABETIC RETINOPATHY

Rodrigues, Tiago M., MD, MSc*,†; Marques, João P., MD, MSc*,‡,§; Soares, Mário, BSc, Optom*; Dolan, Michael-John, PhD; Melo, Pedro, BSc, Optom*; Simão, Sílvia, MSc§; Teles, João, BSc; Figueira, João, MD, PhD*,‡,§; Murta, Joaquim N., MD, PhD*,‡,§; Silva, Rufino, MD, PhD*,‡,§

doi: 10.1097/IAE.0000000000002328
Original Study: PDF Only

Purpose: To study radial peripapillary capillary (RPC) density in the early stages of diabetic retinopathy (DR), using optical coherence tomography angiography.

Methods: A cross-sectional evaluation of RPCs was performed using optical coherence tomography angiography (Avanti RTVue-XR 100, Optovue Inc, Fremont, CA). Annular RPC density was the primary outcome. Global density and retinal nerve fiber layer thickness were secondary outcomes. Diabetic eyes were divided into three groups: no DR, mild nonproliferative DR (mild NPDR), and moderate NPDR. Multilevel mixed-effects univariate and multivariate linear regression models were used.

Results: We included 155 eyes (n = 42 control; n = 27 no DR; n = 28 mild NPDR; and n = 58 moderate NPDR) from 86 subjects (mean [SD] age 63.39 [10.70] years; 46.45% male). When compared with controls, a significant decrease in annular RPC density was found in all groups of diabetic eyes on multivariate analysis (no DR: β = −2.95, P < 0.001; mild NPDR: β = −1.76, P = 0.017; and moderate NPDR: β = −2.82, P < 0.001). We also detected a significant decrease in retinal nerve fiber layer thickness in diabetic eyes (even in the no DR group). Furthermore, in diabetic eyes, annular RPC density and retinal nerve fiber layer thickness correlated significantly (R = 0.4874, P < 0.001).

Conclusion: Peripapillary neurovascular changes occur early in the course of DR. Their significance in the progression of DR warrants further research.

This cross-sectional, prospectively defined, observational study demonstrates that the density of perfused peripapillary capillaries, evaluated with optical coherence tomography angiography, is decreased in eyes of diabetic patients with early diabetic retinopathy, but also when clinical signs of retinopathy were absent. Peripapillary vascular changes may occur early in disease progression.

*Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), E.P.E. Praceta Professor Mota Pinto, Coimbra, Portugal;

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa, Portugal;

Faculty of Medicine, University of Coimbra (FMUC), Rua Larga, Coimbra, Portugal;

§Association for Innovation and Biomedical Research on Light and Imaging (AIBILI), Azinhaga de Santa Comba, Coimbra, Portugal; and

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia.

Reprint requests: Tiago M. Rodrigues, MD, MSc, Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), E.P.E. Praceta Professor Mota Pinto, Coimbra 3000-075, Portugal; e-mail: tiago.fm.rod@gmail.com

Presented at the 5th International Congress on OCT Angiography, “en face” OCT and advances in OCT; AP Meetings, Rome, Italy, December 15 and 16, 2017.

None of the authors has any financial/conflicting interests to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.retinajournal.com).

© 2018 by Ophthalmic Communications Society, Inc.