Share this article on:


Khanani, Arshad M., MD, MA*; Eichenbaum, David, MD†,**; Schlottmann, Patricio G., MD; Tuomi, Lisa, PharmD§; Sarraf, David, MD‖,¶

doi: 10.1097/IAE.0000000000002195
Review: PDF Only

Purpose: This review aimed to determine the optimal management of retinal pigment epithelial detachments (PEDs) in neovascular age-related macular degeneration (nAMD) based on review of available evidence in the literature.

Methods: A comprehensive literature review evaluates previous retrospective and prospective studies that assessed the treatment of PEDs in nAMD.

Results: Studies illustrated that anti–vascular endothelial growth factor (VEGF) therapy can be effective in eyes with PED secondary to nAMD. Similar visual outcomes are associated with different anti-VEGF treatments. Higher anti-VEGF doses may improve anatomical response, without correlation with vision improvement. Fibrovascular PEDs may be difficult to treat, but even these eyes can gain vision with anti-VEGF therapy. A retinal pigment epithelial tear may develop in 15% to 20% of eyes with PEDs after anti-VEGF therapy, especially in PEDs greater than 500 µm to 600 µm in height; however, vision may stabilize with continued therapy. Atrophy may complicate eyes with PED and nAMD after anti-VEGF therapy, especially in association with complete PED resolution.

Conclusion: Available literature suggests that anti-VEGF therapy is safe and efficacious for PED and nAMD. Treatment should focus on vision gains rather than PED resolution because there is no apparent correlation between anatomical and functional improvement in most eyes with PED and nAMD.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

A comprehensive literature search suggests that anti–vascular endothelial growth factor therapy is effective in treating eyes with pigment epithelial detachment due to neovascular age-related macular degeneration. This therapy should focus primarily on vision gains because there is no apparent correlation between anatomical and functional improvement in most eyes with pigment epithelial detachment and neovascular age-related macular degeneration.

*Sierra Eye Associates, Reno, Nevada;

Retina Vitreous Associates of Florida, Tampa, Florida;

Organizacion Medica de Investigacion, Buenos Aires, Argentina;

§Genentech, Inc, South San Francisco, California;

Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California, Los Angeles, Los Angeles, California;

Greater Los Angeles VA Healthcare Center, Los Angeles, California; and

**Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida.

Reprint requests: Arshad M. Khanani, MD, MA, Sierra Eye Associates, 950 Ryland Street, Reno, Nevada 89502; e-mail:

Third-party writing assistance was provided by Jack W. Pike, PhD, of Envision Scientific Solutions, and funded by Genentech, Inc.

A. M. Khanani: Supported Research: Aerpio, Alcon, Allergan, DigiSight, Genentech, Inc, Novartis, Ophthotech, ThromboGenics; Consultant/Advisor: Aerpio, Alcon, Alimera, Allergan, Genentech, Inc, Novartis, ThromboGenics; Speaker: Allergan, Genentech, Inc, Novartis Pharma, D. Eichenbaum: Consultant/Advisor: Alimera, Allergan, Genentech, Inc, Regeneron, ThromboGenics; Supported Research: Alcon, Alimera, Allergan, Clearside, Genentech, Inc, Ophthotech, River Vision, ThromboGenics, TOGA Trial; Speaker: Allergan, Genentech, Inc; Equity: Boston Image Reading Center, Hemera Biopharmaceuticals, USRetina, P. Schlottmann: Advisor: Bayer, Novartis, Roche; Travel grants: Allergan, Bayer, Novartis. L. Tuomi: Employee of Genentech, Inc. D. Sarraf: Consultant: Amgen, Bayer, Genentech, Inc, Novartis, Nuvelution, Optovue; Research support: Allergan, Genentech, Inc, Heidelberg, Optovue, Regeneron; Speaker: Novartis, Optovue.

Genentech, Inc participated in the design and conduct of the study; data collection, analysis, and interpretation of results; and preparation, review, and approval of the manuscript, but had no role in the conduct of this research or final clinical interpretation of the data.

© 2018 by Ophthalmic Communications Society, Inc.