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OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL AVASCULAR ZONE IN CHILDREN WITH A HISTORY OF TREATMENT-REQUIRING RETINOPATHY OF PREMATURITY

Nonobe, Norie, MD, PhD*; Kaneko, Hiroki, MD, PhD*; Ito, Yasuki, MD, PhD*; Takayama, Kei, MD, PhD*,†; Kataoka, Keiko, MD, PhD*; Tsunekawa, Taichi, MD*; Matsuura, Toshiyuki, MD*; Suzumura, Ayana, MD*; Shimizu, Hideyuki, MD*; Terasaki, Hiroko, MD, PhD*

doi: 10.1097/IAE.0000000000001937
Original Study: PDF Only

Purpose: To examine the characteristics of the foveal vascular structure of patients with retinopathy of prematurity (ROP) by optical coherence tomography angiography.

Methods: Ten patients with a history of laser photocoagulation or cryopexy treatment for Stage 3 (Zone ≥ II) ROP and 10 normal subjects (controls) were included. Foveal avascular zone, vessel density, vessel length, and vascular diameter index were measured by optical coherence tomography angiography using the 3 × 3-mm Early Treatment Diabetic Retinopathy Study (ETDRS) sectors.

Results: The median foveal avascular zone values of the patients with ROP and controls were 0.103 mm2 and 0.260 mm2, respectively (P = 0.0025). The medians of the vessel density, vessel length, and vascular diameter index of the patients with ROP were 0.218 mm2/mm2, 11.75 mm/mm2, and 18.00 μm, respectively, in ETDRS Sector 1 and did not significantly differ from those of the controls (P = 0.940, 0.733, and 0.705, respectively). For the average of ETDRS Sectors 2 to 5, the medians of the vessel density, vessel length, and vascular diameter index for the patients with ROP were 0.347 mm2/mm2, 18.95 mm/mm2, and 18.28 μm, respectively; vessel density and vessel length were significantly smaller than those of the controls (P = 0.002 and 0.003, respectively), but there was no significant difference in vascular diameter index (P = 0.286).

Conclusion: Optical coherence tomography angiography–guided foveal avascular zone was significantly smaller in patients with ROP than in controls. Our results indicate that foveal vascular development may be altered in patients with a history of treatment-requiring ROP.

Optical coherence tomography angiography–guided analysis revealed that foveal avascular zone in retinopathy of prematurity was significantly smaller than in control. In addition, vessel density and vessel length of the patients with retinopathy of prematurity in ETDRS Sectors 2 to 5 were significantly smaller than those of the controls. Our results indicated foveal vascularity development immaturity in patients with retinopathy of prematurity.

*Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan; and

Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan.

Reprint requests: Hiroko Terasaki, MD, PhD, Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi 466-8550, Japan; e-mail: terasaki@med.nagoya-u.ac.jp

Grant-in-Aid for Scientific Research B (15H04994) and Grant-in-Aid for Young Scientist B (17K16963) from the Ministry of Education, Culture, Sports, Science, and Technology (http://www.jsps.go.jp/); Chukyo Longevity Medical and Promotion Foundation; Takeda Science Foundation; and The Hori Science and Arts Foundation.

None of the authors has any conflicting interests to disclose.

N. Nonobe and H. Kaneko authors contributed equally to this work.

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© 2018 by Ophthalmic Communications Society, Inc.