To study correlations in patients with retinal vein occlusion between the automatically quantified macular vascular densities in the superficial and deep capillary plexus (DCP) obtained using optical coherence tomography angiography (OCTA) and the data from conventional examination, particularly visual acuity and peripheral retinal nonperfusion assessed using fluorescein angiography (FA).
Retrospective, observational study of patients with retinal vein occlusion who underwent a comprehensive ophthalmic examination including FA and OCTA using the AngioVue OCTA system version 2015.100.0.35 (OptovueRTVue XR 100; AVANTI, Inc, Fremont, CA). Vascular densities in the superficial capillary plexus and DCP, as well as the area of the foveal avascular zone, were measured using the AngioAnalytics software.
Our study of 65 eyes of 61 patients (33 men, mean age: 67 years) showed a significant correlation between peripheral nonperfusion on FA and (1) automatically quantified global vascular density in both plexus (P = 0.021 for the DCP) and (2) foveal avascular zone area (P = 0.037). We also found significant correlations between capillary dropouts in both plexus and peripheral nonperfusion (P < 0.001 for both) and between visual acuity and vascular densities (P = 0.002 for the global density in the DCP). Global density less than 46% in the DCP was associated to the presence of peripheral nonperfusion area on FA (P = 0.003) and to enlargement of the superficial foveal avascular zone (P = 0.002).
Our study demonstrated a significant correlation between automatically quantified macular vascular density on OCTA and peripheral nonperfusion on FA; OCTA could help identify high-risk retinal vein occlusion patients who may benefit from further evaluation using FA.
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Optical coherence tomography angiography is a noninvasive examination, which allowed automated measurements of vascular density at the level of the superficial and deep capillary plexus. Correlations were found in patients with retinal vein occlusion between the automatically quantified macular vascular densities obtained using optical coherence tomography angiography and the data obtained from conventional examination, particularly visual acuity and peripheral retinal nonperfusion assessed using fluorescein angiography.
Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Université Paris-Est-Créteil, Paris 12 University, Créteil, France.
Reprint requests: Florence Coscas, MD, Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, 40 Avenue Verdun, Université Paris Est, 94010 Créteil, France; e-mail: email@example.com
None of the authors has any financial/conflicting interests to disclose.